Simethicone

Active ingredient description

Simethicone is a chemically inert, non-systemic gastric defoaming agent that works by altering the elasticity of interfaces of mucus-embedded bubbles in the gastrointestinal tract. The gas bubbles are thus broken down or coalesced and in this form gas is more easily eliminated through eructation or passing flatus.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
Silicones
A Alimentary tract and metabolism → A03 Drugs for functional gastrointestinal disorders → A03A DRUGS FOR FUNCTIONAL BOWEL DISORDERS → A03AX Other drugs for functional bowel disorders
Discover more medicines within A03AX13

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
Summary of Product Characteristics (SPC)
UK

Medicines

Simethicone is the active ingredient of these drugs:

Drug
Countries

Ecuador

Spain

Hong Kong

Hong Kong

Austria Estonia Lithuania

Hong Kong

Poland

Hong Kong

New Zealand

Hong Kong Ireland United Kingdom

Ecuador

Ecuador

Brazil

Brazil

Finland

Spain

Germany

Ecuador

Estonia Germany Lithuania Poland

Ecuador

Hong Kong

Ecuador

Ecuador

Hong Kong

Hong Kong

Hong Kong

Ecuador

Germany

Spain

Canada Cyprus Hong Kong Poland United Kingdom

Austria Germany

Germany

Mexico

Brazil

Singapore

Ecuador

Canada

Canada

Hong Kong

Singapore

Austria Estonia Germany

Hong Kong

France

Singapore

Ecuador

Hong Kong

Hong Kong

Germany

United Kingdom

United Kingdom

Simethicone is also found within below combination drugs:

ACIFIN , ACITIP , ACOLIC , ACTAL PLUS , ACTIBUTIN S , ACTONORM , ALEVIAN DUO , ALLUMAG MPS , ALMAGCON , ALMAGEL NEO , ALMECON , ALMETIN , ALOPER , ALTACITE PLUS , ALUMAG PLUS , ANMAX , ANTACIN-IMP , ANTAD , ANTASINE-D , ANTIAX , AVARIN , BARCALONA , BEATACID , BERCLOMIN , BILIDREN ENZIMATICO , BIO-GASTAL , BOTHEME , BUENOX , CARBEX , CARBOSYLANE , CARBOSYMAG , CENVITE , CLENSIA , CLODOPAN GAS , COLIMIX , COLYPAN PLUS , DICETEL DUO , DICYMINE CO , DIGECAP PLUS , DIGECAP ZIMATICO , DIGERIL , DIGESCONA PLUS , DIGESFLAT , DIGESGAS PLUS , DIMEGEL , DIMOFLAX , DIOVOL PLUS , DIOVOL PLUS ALUMINUM FREE , DITOPAX , DOLOSPASMYL , DUOSED EXTRA STOMACH , EDERAL , ENDIAL DIGEST , ESPAVEN , EUTRANSIL S , EVILINE , FEDRA-GEL-S , FLATICONA , FLATORIL , FLATUGEL , FORTASEC PLUS , GASEDIN-U , GASTRIKON , GASTRINOX , GASTROFAST ADVANCE , GASTROGEL , GELMAX DIM , GELUSIL PLUS , GESTIVA , HELOPANFLAT , HYDROSIL , IMODIUM ADVANCED , IMODIUM COMPLETE , IMODIUM DUAL ACTION , IMODIUM DUO , IMODIUM PLUS , KOLANTICON , LANTACID , LEPRIT ENZIMATICO , LIBERTRIM SDP , LIBERTRIM SII , MAALOX PLUS , MAGALCID , MAGANYL , MAGEN , MAGNAZIA , MAGSIL , MANTI , MEGAGEL , MERASYN , METEOSPASMYL , METEOXANE , MOSAR PLUS , MOTRIXSIM PLUS , MOXAR SI , MUVETT S , MYLANTA , MYLANTA PLUS , MYTANCID , NUTRIZYM PLUS , PANASID , PANKREOLIVE , POLYSILANE DELALANDE , POLYSILIC , PRAMIGEL , PRODIGEST , PROLIN , REGAST , RIOPONE PLUS , RUBRAGEL , SILOX , SIMAGAL , SIMALVIA , SIMECO , SIMEGEL , SINACIDE-S , SINWELL , SINWILCON , SISDIAL , SPASMALVEX , STAMYL FORTE , STOMGEL , STOPERAN S , SUNTACID , TRILOXANE-S , TRILOZANE , U-LANTA , ULCOGEL EXTRA STOMACH , UNI-DROSIL , VYLING VYFUNSIL , WELMAGEL , WIND RELIEF , XIMEPEG , ZANTARIS , ZIGATAB

Chemical formula: C₆H₁₈O₄Si₃
Molecular mass: 238.461 g/mol

External identifiers

CAS Substance: 63148-62-9
DrugBank Drug: DB09512
KEGG Drug: D05841
PubChem Compound: 6433516
RxNorm Ingredient: 9778
SNOMED-CT Concept: 387442005
Simeticone (substance)