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ATC Group: A03A DRUGS FOR FUNCTIONAL BOWEL DISORDERS

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A03
Drugs for functional gastrointestinal disorders
3
A03A
DRUGS FOR FUNCTIONAL BOWEL DISORDERS

Contents

Code
Title
A03AA
Synthetic anticholinergics, esters with tertiary amino group
A03AB
Synthetic anticholinergics, quaternary ammonium compounds
A03AC
Synthetic antispasmodics, amides with tertiary amines
A03AD
Papaverine and derivatives
A03AE
Drugs acting on serotonin receptors
A03AX
Other drugs for functional bowel disorders

Active Ingredients

Chemical substance
Description
Alosetron

Alosetron is a potent and selective 5-HT3 receptor antagonist. 5-HT3 receptors are ligand-gated cation channels that are extensively distributed on enteric neurons in the human gastrointestinal tract, as well as other peripheral and central locations.

Alverine
Caroverine
Dicycloverine

Dicyclomine relieves smooth muscle spasm of the gastrointestinal tract and is used for the treatment of patients with functional bowel/irritable bowel syndrome. It can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function.

Dimeticone

Dimeticone is used in many pharmaceutical and cosmetic preparations. A 4% concentration has been found to affect the physico-physiological activity of lice.

Drotaverine
Glycopyrronium

Glycopyrronium is an inhaled long-acting muscarinic receptor antagonist (anticholinergic) for once-daily maintenance bronchodilator treatment of COPD. Glycopyrronium works by blocking the bronchoconstrictor action of acetylcholine on airway smooth muscle cells, thereby dilating the airways.

Isometheptene
Mebeverine

Mebeverine is a musculotropic antispasmodic with a direct action on the smooth muscle of the gastrointestinal tract, relieving spasm without affecting normal gut motility.

Otilonium bromide

Otilonium bromide is endowed with a marked spasmolytic action on the smooth muscle of the digestive tract.

Phloroglucinol
Pinaverium
Propantheline

Propantheline inhibits parasympathetic activity by blocking the action of the neurohormone, acetylcholine, on the neuroeffector cell. This blocking action of propantheline is instrumental in reducing gastric acid secretion and gastrointestinal motor activity.

Simethicone

Simethicone is a chemically inert, non-systemic gastric defoaming agent that works by altering the elasticity of interfaces of mucus-embedded bubbles in the gastrointestinal tract. The gas bubbles are thus broken down or coalesced and in this form gas is more easily eliminated through eructation or passing flatus.

Trimebutine

Trimebutine maleate is a noncompetitive spasmolytic agent. It possesses moderate opiate receptor affinity and has a marked antiserotonin activity especially on ‘M’ receptors. It induces regulation of spontaneous activity and increases synchronization between electrophysiological spikes and contractions in isolated guinea pig taenia coli and ileum. However, it does not alter normal motility, but regulates abnormal intestinal activity.

Monographs

Monograph
Type
Country
AUROBEVERINE Modified-release capsule, hard
MPI, EU: SmPC
UK
COLOFAC Coated tablet
MPI, EU: SmPC
UK
COLOFAC Modified release capsule
MPI, EU: SmPC
UK
CUVPOSA Oral solution
MPI, US: SPL/PLR
US
INFACOL Oral suspension
MPI, EU: SmPC
UK
PRO-BANTHINE Tablet
MPI, EU: SmPC
UK
SIALANAR Oral solution
MPI, EU: SmPC
UK