ATC Group: A03AA Synthetic anticholinergics, esters with tertiary amino group

Anatomical Therapeutic Chemical Classification System

Hierarchical position in ATC classification

Level
Code
Title
1
Alimentary tract and metabolism
2
Drugs for functional gastrointestinal disorders
3
DRUGS FOR FUNCTIONAL BOWEL DISORDERS
4
A03AA
Synthetic anticholinergics, esters with tertiary amino group

ATC group contents

Code
Title
Oxyphencyclimine
Camylofin
Mebeverine
Trimebutine
Rociverine
Dicycloverine
Dihexyverine
Difemerine
Piperidolate

Active ingredients

Active Ingredient
Description

Dicyclomine relieves smooth muscle spasm of the gastrointestinal tract and is used for the treatment of patients with functional bowel/irritable bowel syndrome. It can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function.

Mebeverine is a musculotropic antispasmodic with a direct action on the smooth muscle of the gastrointestinal tract, relieving spasm without affecting normal gut motility.

Trimebutine maleate is a noncompetitive spasmolytic agent. It possesses moderate opiate receptor affinity and has a marked antiserotonin activity especially on ‘M’ receptors. It induces regulation of spontaneous activity and increases synchronization between electrophysiological spikes and contractions in isolated guinea pig taenia coli and ileum. However, it does not alter normal motility, but regulates abnormal intestinal activity.

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