PREZCOBIX

This brand name is authorized in Australia, Canada, Hong Kong, Japan, United States

Active ingredients

The drug PREZCOBIX contains a combination of these active pharmaceutical ingredients (APIs):

1 Darunavir
UNII 33O78XF0BW - DARUNAVIR ETHANOLATE

Darunavir is an inhibitor of the dimerisation and of the catalytic activity of the HIV-1 protease (KD of 4.5 × 10-12 M). It selectively inhibits the cleavage of HIV encoded Gag-Pol polyproteins in virus infected cells, thereby preventing the formation of mature infectious virus particles.

Read about Darunavir
2 Cobicistat
UNII LW2E03M5PG - COBICISTAT

Cobicistat is a mechanism-based inhibitor of cytochromes P450 of the CYP3A subfamily. Inhibition of CYP3A-mediated metabolism by cobicistat enhances the systemic exposure of CYP3A substrates, such as darunavir, where bioavailability is limited and half-life is shortened due to CYP3A-dependent metabolism.

Read about Cobicistat

Medication package inserts

Below package inserts are available for further reading:

Title Information Source Document Type  
PREZCOBIX Film-coated tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
J05AR14 Darunavir and cobicistat J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AR Antivirals for treatment of HIV infections, combinations
Discover more medicines within J05AR14

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: AU Pharmaceutical Benefits Scheme Identifier(s): 10903W
Country: CA Health Products and Food Branch Identifier(s): 02426501
Country: HK Department of Health Drug Office Identifier(s): 64960
Country: JP 医薬品医療機器総合機構 Identifier(s): 6250110F1028
Country: US FDA, National Drug Code Identifier(s): 59676-575

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