Chemical formula: C₂₇H₃₇N₃O₇S Molecular mass: 547.664 g/mol PubChem compound: 213039
Darunavir is an inhibitor of the dimerisation and of the catalytic activity of the HIV-1 protease (KD of 4.5 × 10-12 M). It selectively inhibits the cleavage of HIV encoded Gag-Pol polyproteins in virus infected cells, thereby preventing the formation of mature infectious virus particles.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| J05AE10 | Darunavir | J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AE Protease inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| DARUNAVIR KRKA 400 mg / 800 mg Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC | |
| DARUNAVIR KRKA 600 mg Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Darunavir is an active ingredient of these brands:
United States (US)Australia (AU)Austria (AT)Brazil (BR)
Canada (CA)Estonia (EE)Finland (FI)France (FR)Hong Kong (HK)Ireland (IE)Japan (JP)Lithuania (LT)Mexico (MX)
Netherlands (NL)New Zealand (NZ)
Nigeria (NG)Poland (PL)Romania (RO)Singapore (SG)
South Africa (ZA)
Spain (ES)Turkey (TR)
United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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