SYMKEVI

This brand name is authorized in Austria, Estonia, Spain, Finland, Ireland, Lithuania, Netherlands, Poland, Romania, United Kingdom

Active ingredients

The drug SYMKEVI contains a combination of these active pharmaceutical ingredients (APIs):

1 Tezacaftor
UNII 8RW88Y506K - TEZACAFTOR
2 Ivacaftor
UNII 1Y740ILL1Z - IVACAFTOR

Ivacaftor is a potentiator of the CFTR protein, i.e., in vitro ivacaftor increases CFTR channel gating to enhance chloride transport in specified gating mutations with reduced channel-open probability compared to normal CFTR. Ivacaftor also potentiated the channel-open probability of R117H-CFTR, which has both low channel-open probability (gating) and reduced channel current amplitude (conductance).

Read about Ivacaftor

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
R07AX31 R Respiratory system → R07 Other respiratory system products → R07A Other respiratory system products → R07AX Other respiratory system products
Discover more medicines within R07AX31

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: EE Ravimiamet Identifier(s): 1782390, 1834028
Country: ES Centro de información online de medicamentos de la AEMPS Identifier(s): 1181306001
Country: FI Lääkealan turvallisuus- ja kehittämiskeskus Identifier(s): 396604
Country: GB Medicines & Healthcare Products Regulatory Agency Identifier(s): 367455, 391985
Country: IE Health Products Regulatory Authority Identifier(s): 88845, 89045
Country: LT Valstybinė vaistų kontrolės tarnyba Identifier(s): 1086559, 1091497
Country: NL Z-Index G-Standaard, PRK Identifier(s): 197424
Country: PL Rejestru Produktów Leczniczych Identifier(s): 100413101, 100446589
Country: RO Agenția Națională a Medicamentului și a Dispozitivelor Medicale Identifier(s): W67229001, W67230001

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