Ivacaftor

Chemical formula: C₂₄H₂₈N₂O₃  Molecular mass: 392.491 g/mol  PubChem compound: 16220172

Active ingredient description

Ivacaftor is a potentiator of the CFTR protein, i.e., in vitro ivacaftor increases CFTR channel gating to enhance chloride transport in specified gating mutations with reduced channel-open probability compared to normal CFTR. Ivacaftor also potentiated the channel-open probability of R117H-CFTR, which has both low channel-open probability (gating) and reduced channel current amplitude (conductance).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
R07AX02 R Respiratory system → R07 Other respiratory system products → R07A Other respiratory system products → R07AX Other respiratory system products
Discover more medicines within R07AX02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
KALYDECO Granules European Medicines Agency (EU) MPI, EU: SmPC
KALYDECO Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 873054-44-5
DrugBank Drug: DB08820
KEGG Drug: D09916
PubChem Compound: 16220172
RxNorm Ingredient: 1243041
SNOMED-CT Concept: 703823007
Ivacaftor (substance)
UNII Identifier: 1Y740ILL1Z
IVACAFTOR

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