TS-ONE

This brand name is authorized in Hong Kong, Singapore

Active ingredients

The drug TS-ONE contains a combination of these active pharmaceutical ingredients (APIs):

1
UNII UA8SE1325T - GIMERACIL
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2
UNII 4R7FFA00RX - OTERACIL POTASSIUM
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3 Tegafur
UNII 1548R74NSZ - TEGAFUR

Tegafur is a prodrug of 5-FU with good oral bioavailability. Following oral administration, tegafur is gradually converted to 5-FU in vivo, mainly by CYP2A6 enzyme activity in the liver. 5-FU is metabolised by the liver enzyme DPD. 5-FU is activated within cells by phosphorylation to its active metabolite, 5-fluoro-deoxyuridine-monophosphate (FdUMP). FdUMP and reduced folate are bound to thymidylate synthase leading to formation of a ternary complex which inhibits DNA synthesis. In addition, 5-fluorouridine-triphosphate (FUTP) is incorporated into RNA causing disruption of RNA functions.

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Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
L01BC53 Tegafur, combinations L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BC Pyrimidine analogues
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Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: HK Department of Health Drug Office Identifier(s): 61181, 61182
Country: SG Health Sciences Authority Identifier(s): 13672P, 13673P

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