Tegafur

Chemical formula: C₈H₉FN₂O₃  Molecular mass: 200.169 g/mol  PubChem compound: 5386

Active ingredient description

Tegafur is a prodrug of 5-FU with good oral bioavailability. Following oral administration, tegafur is gradually converted to 5-FU in vivo, mainly by CYP2A6 enzyme activity in the liver. 5-FU is metabolised by the liver enzyme DPD. 5-FU is activated within cells by phosphorylation to its active metabolite, 5-fluoro-deoxyuridine-monophosphate (FdUMP). FdUMP and reduced folate are bound to thymidylate synthase leading to formation of a ternary complex which inhibits DNA synthesis. In addition, 5-fluorouridine-triphosphate (FUTP) is incorporated into RNA causing disruption of RNA functions.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01BC03 Tegafur L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BC Pyrimidine analogues
Discover more medicines within L01BC03

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 17902-23-7
DrugBank Drug: DB09256
KEGG Drug: D01244
PubChem Compound: 5386
RxNorm Ingredient: 4582
SNOMED-CT Concept: 395897006
Tegafur (substance)
UNII Identifier: 1548R74NSZ
TEGAFUR

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