VORACTIV

This brand name is authorized in United Kingdom

Active ingredients

The drug VORACTIV contains a combination of these active pharmaceutical ingredients (APIs):

1 Rifampicin
UNII VJT6J7R4TR - RIFAMPIN

Rifampicin is an active bactericidial antituberculosis drug which is particularly active against the rapidly growing extracellular organisms and also has bactericidial activity intracellularly. Rifampicin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

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2 Isoniazid
UNII V83O1VOZ8L - ISONIAZID

Isoniazid is used mainly in the treatment of pulmonary tuberculosis but it appears to be effective also in the treatment of extrapulmonary lesions, including meningitis and genito-urinary disease.

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3 Pyrazinamide
UNII 2KNI5N06TI - PYRAZINAMIDE

Pyrazinamide exhibits tuberculostatic activity. Pyrazinamide is active only at an acid pH, and it is therefore active mainly on the tubercle bacilli located within the cell.

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4 Ethambutol
UNII QE4VW5FO07 - ETHAMBUTOL HYDROCHLORIDE

Ethambutol is bacteriostatic. It is effective against Mycobacterium tuberculosi and M.bovis with an MIC of 0.5–8ยตg per ml. The exact mechanism of action is unknown. While it has activity against some atypical mycobacteria including M.Kansasii, activity against other micro-organisms has not yet been reported.

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Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
J04AM06 Rifampicin, pyrazinamide, ethambutol and isoniazid J Antiinfectives for systemic use → J04 Antimycobacterials → J04A Drugs for treatment of tuberculosis → J04AM Combinations of drugs for treatment of tuberculosis
Discover more medicines within J04AM06

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: GB Medicines & Healthcare Products Regulatory Agency Identifier(s): 217199

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