ICD-10 Specific code E84.8: Cystic fibrosis with other manifestations
Specific codes in ICD-10 are unique alphanumeric designations used to identify and categorize diseases, disorders, and conditions. They consist of 3-5 characters, including both letters and numbers, that provide a high level of detail and specificity.
Translations
| Language | Translation |
|---|---|
English
|
Cystic fibrosis with other manifestations |
French
|
Fibrose kystique avec autres manifestations |
Hierarchical position
| Level | Code | Title | |
|---|---|---|---|
| 1 | IV | Endocrine, nutritional and metabolic diseases | |
| 2 | E70-E90 | Metabolic disorders | |
| 3 | E84 | Cystic fibrosis | |
| 4 | E84.8 | Cystic fibrosis with other manifestations |
Indicated medicines
| Active Ingredient |
|---|
|
Recombinant human DNase is a genetically engineered version of a naturally occurring human enzyme which cleaves extracellular DNA. In vitro, dornase alfa hydrolyses DNA in sputum and greatly reduces the viscoelasticity of cystic fibrosis sputum. |
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Ivacaftor is a potentiator of the CFTR protein, i.e., in vitro ivacaftor increases CFTR channel gating to enhance chloride transport in specified gating mutations with reduced channel-open probability compared to normal CFTR. Ivacaftor also potentiated the channel-open probability of R117H-CFTR, which has both low channel-open probability (gating) and reduced channel current amplitude (conductance). |
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Mannitol is a naturally occurring sugar alcohol used clinically primarily for its osmotic diuretic properties. |