Active Ingredient: Lisinopril
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, between 2.5 milligrams lisinopril and 10 milligrams lisinopril, once daily. Afterwards, oral, between 20 milligrams lisinopril and 80 milligrams lisinopril, once daily. The maximum allowed total dose is 80 milligrams lisinopril daily.
The dose should be individualised according to patient profile and blood pressure response.
Lisinopril may be used as monotherapy or in combination with other classes of antihypertensive therapy.
In patients with hypertension the usual recommended starting dose is 10 mg. Patients with a strongly activated reninangiotensin-aldosterone system (in particular, renovascular hypertension, salt and/or volume depletion, cardiac decompensation, or severe hypertension) may experience an excessive blood pressure fall following the initial dose. A starting dose of 2.5-5 mg is recommended in such patients and the initiation of treatment should take place under medical supervision. A lower starting dose is required in the presence of renal impairment.
The usual effective maintenance dosage is 20 mg administered in a single daily dose. In general, if the desired therapeutic effect cannot be achieved in a period of 2 to 4 weeks on a certain dose level, the dose can be further increased. The maximum dose used in long-term, controlled clinical trials was 80 mg/day.
As with other ACE inhibitors, lisinopril may be less effective in lowering blood pressure in black patients than in non-blacks, possibly because of a higher prevalence of low-renin states in the black hypertensive population.
Lisinopril should be taken at approximately the same time each day. The absorption of lisinopril is not affected by food.
For:
Regimen A: In case that patient weight is ≥ 20 kg and patient weight is ≤ 50 kg, oral, 2.5 milligrams lisinopril, once daily. Afterwards, in case that patient weight is ≥ 20 kg and patient weight is ≤ 50 kg, oral, between 2.5 milligrams lisinopril and 20 milligrams lisinopril, once daily. The maximum allowed total dose is 20 milligrams lisinopril daily.
Regimen B: In case that patient weight is ≥ 50 kg, oral, 5 milligrams lisinopril, once daily. Afterwards, in case that patient weight is ≥ 50 kg, oral, between 5 milligrams lisinopril and 40 milligrams lisinopril, once daily. The maximum allowed total dose is 40 milligrams lisinopril daily.
The dose should be individualised according to patient profile and blood pressure response.
Lisinopril may be used as monotherapy or in combination with other classes of antihypertensive therapy.
The recommended initial dose is 2.5 mg once daily in patients 20 to <50 kg, and 5 mg once daily in patients ≥50 kg. The dosage should be individually adjusted to a maximum of 20 mg daily in patients weighing 20 to <50 kg, and 40 mg in patients ≥50 kg. Doses above 0.61 mg/kg (or in excess of 40 mg) have not been studied in paediatric patients.
In children with decreased renal function, a lower starting dose or increased dosing interval should be considered.
As with other ACE inhibitors, lisinopril may be less effective in lowering blood pressure in black patients than in non-blacks, possibly because of a higher prevalence of low-renin states in the black hypertensive population.
Lisinopril should be taken at approximately the same time each day. The absorption of lisinopril is not affected by food.
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