Lisinopril

Chemical formula: C₂₁H₃₁N₃O₅  Molecular mass: 405.488 g/mol  PubChem compound: 5362119

Active ingredient description

Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin-converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of angiotensin II which results in decreased vasopressor activity and reduced aldosterone secretion.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C09AA03 Lisinopril C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09A ACE inhibitors, plain → C09AA ACE inhibitors, plain
Discover more medicines within C09AA03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
PRINIVIL Tablet FDA, National Drug Code (US) MPI, US: SPL/PLR
ZESTRIL Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ZESTRIL Tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 76547-98-3
CAS Substance: 83915-83-7
DrugBank Drug: DB00722
KEGG Drug: D00362
PubChem Compound: 5362119
RxNorm Ingredient: 29046
SNOMED-CT Concept: 386873009
Lisinopril (substance)
UNII Identifier: E7199S1YWR
LISINOPRIL

Medicines

Lisinopril is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Italy (IT)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

  • (combination) ZESTORETIC as Lisinopril dihydrate

Netherlands (NL)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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