Hodgkin's lymphoma

Active Ingredient: Bleomycin

Indication for Bleomycin

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

5,000-15,000 IU/m² once or twice a week

Route of admnistration

Intramuscular

Defined daily dose

5,000 - 15,000 [iU] per m² of body surface area (BSA)

Dosage regimen

From 5,000 To 15,000 [iU] per m² of body surface area (BSA) once every 7 day(s)

Detailed description

When used alone, intramuscular or intravenous injection of 5-15 × 103 IU/m² BSA, once or twice a week, up to a cumulative total dose of 225 × 103 IU. Because of the possibility of anaphylactoid reactions, lymphoma patients should be treated with lower doses (for instance 2 × 103 IU) for the first two applications. If there are no acute reactions after 4 hours of observation, the normal dose schedule can be followed.

Dosage considerations

Dissolve the contents of a vial in 1-5 mL physiological saline solution. Since repeated i.m. injections at the same site can cause local discomfort, it is recommended to change the injection site regularly. In the event of excessive local discomfort, a local anaesthetic can be added to the injection solution, e.g. 1.5-2 mL lidocaine HCl 1%.

5,000-15,000 IU/m² once or twice a week

Route of admnistration

Intravenous

Defined daily dose

5,000 - 15,000 [iU] per m² of body surface area (BSA)

Dosage regimen

From 5,000 To 15,000 [iU] per m² of body surface area (BSA) once every 7 day(s)

Detailed description

When used alone, intramuscular or intravenous injection of 5-15 × 103 IU/m² BSA, once or twice a week, up to a cumulative total dose of 225 × 103 IU. Because of the possibility of anaphylactoid reactions, lymphoma patients should be treated with lower doses (for instance 2 × 103 IU) for the first two applications. If there are no acute reactions after 4 hours of observation, the normal dose schedule can be followed.

Dosage considerations

Intravenous injection

Dissolve the contents of a vial in 5-10 mL physiological saline solution and inject slowly over a period of 5-10 minutes. Fast bolus injections are to be avoided, because they lead to high intrapulmonary plasma concentrations, increasing the risk of lung damage.

Intravenous infusion

Dissolve the contents of a vial in 200-1,000 mL physiological saline solution.

Active ingredient

Bleomycin

Bleomycin is a mixture of basic, water-soluble glycopeptide-antibiotics with cytotoxic activity. Bleomycin acts by interacting with both single and double-stranded DNA (deoxyribonucleic acid) leading to both single and double-strand scission, which leads in turn to inhibition of cell division, inhibition of growth and inhibition of DNA synthesis. Bleomycin can also influence RNA (ribonucleic acid) and protein biosynthesis to a lesser extent.

Read more about Bleomycin

Related medicines

Develop a tailored medication plan for your case, considering factors such as age, gender, and health history

Ask the Reasoner

Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.