Bleomycin
Chemical formula: C₅₅H₈₄N₁₇O₂₁S₃⁺ Molecular mass: 1,415.552 g/mol PubChem compound: 5360373
Active ingredient description
Bleomycin is a mixture of basic, water-soluble glycopeptide-antibiotics with cytotoxic activity. Bleomycin acts by interacting with both single and double-stranded DNA (deoxyribonucleic acid) leading to both single and double-strand scission, which leads in turn to inhibition of cell division, inhibition of growth and inhibition of DNA synthesis. Bleomycin can also influence RNA (ribonucleic acid) and protein biosynthesis to a lesser extent.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| L01DC01 | Bleomycin | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01D Cytotoxic antibiotics and related substances → L01DC Other cytotoxic antibiotics |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| BLEOMYCIN Powder for solution for injection | MPI, EU: SmPC | Medicines & Healthcare Products Regulatory Agency (GB) |
Medicines
Bleomycin is an active ingredient of these brands:
Brazil (BR)Ecuador (EC)Estonia (EE)Hong Kong (HK)
Lithuania (LT)Malta (MT)Netherlands (NL)
Poland (PL)
South Africa (ZA)Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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