Active Ingredient: Avacopan
Avacopan, in combination with a rituximab or cyclophosphamide regimen, is indicated for the treatment of adult patients with severe, active granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA).
For this indication, competent medicine agencies globally authorize below treatments:
60 - 60 mg
From 30 To 30 mg 2 time(s) per day every day
The recommended dose is 30 mg taken orally twice daily, morning and evening, with food.
Avacopan should be administered in combination with a rituximab or cyclophosphamide regimen as follows:
Clinical study data are limited to 52 weeks of exposure followed by 8 weeks of observation.
If a patient misses a dose, the missed dose is to be taken as soon as possible, unless within three hours of the next scheduled dose. If within three hours, then the missed dose is not to be taken.
Treatment must be re-assessed clinically and temporarily stopped if:
Treatment must be temporarily stopped if:
Treatment may be resumed:
If treatment is resumed, hepatic transaminases and total bilirubin are to be monitored closely.
Permanent discontinuation of treatment must be considered if:
The hard capsules are to be taken with food and swallowed whole with water and must not be crushed, chewed, or opened.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.