Avacopan

Chemical formula: C₃₃H₃₅F₄N₃O₂  Molecular mass: 581.656 g/mol  PubChem compound: 49841217

Active ingredient description

Avacopan is a selective antagonist of the human complement 5a receptor (C5aR1 or CD88) and competitively inhibits the interaction between C5aR1 and the anaphylatoxin C5a. The specific and selective blockade of C5aR1 by avacopan reduces the pro-inflammatory effects of C5a, which include neutrophil activation, migration, and adherence to sites of small blood vessel inflammation, vascular endothelial cell retraction and permeability.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
L04AJ05 L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AJ Complement inhibitors
Discover more medicines within L04AJ05

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 TAVNEOS Hard capsule MPI, EU: SmPC European Medicines Agency (EU)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 1346623-17-3
DrugBank Drug: DB15011
KEGG Drug: D11093
PubChem Compound: 49841217
RxNorm Ingredient: 2572100
UNII Identifier: O880NM097T
AVACOPAN

Medicines

Avacopan is an active ingredient of these brands:

Austria (AT)

Croatia (HR)

Estonia (EE)

France (FR)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Lithuania (LT)

Poland (PL)

Spain (ES)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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