Herpes simplex virus (HSV) infections

Active Ingredient: Valaciclovir

Indication for Valaciclovir

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

Valaciclovir is indicated:

  • for the treatment and suppression of HSV infections of the skin and mucous membranes including:
    • treatment of first-episode of genital herpes in immunocompetent adults and adolescents.
    • treatment of recurrences of genital herpes in immunocompetent adults and adolescents.
    • suppression of recurrent genital herpes in immunocompetent adults and adolescents.
  • for the treatment and suppression of recurrent ocular HSV infections in immunocompetent adults and adolescents.

For this indication, competent medicine agencies globally authorize below treatments:

1,000 mg in 2 divided doses daily

Route of admnistration


Defined daily dose

1,000 - 1,000 mg

Dosage regimen

From 500 To 500 mg 2 time(s) per day every day for 5 day(s)

Detailed description

The dose is 500 mg of valaciclovir to be taken twice daily (1,000 mg total daily dose). This dose should be reduced according to creatinine clearance.

For recurrent episodes, treatment should be for three to five days. For initial episodes, which can be more severe, treatment may have to be extended to ten days. Dosing should begin as early as possible.

For recurrent episodes of herpes simplex, this should ideally be during the prodromal period or immediately upon appearance of the first signs or symptoms. Valaciclovir can prevent lesion development when taken at the first signs and symptoms of an HSV recurrence.

Dosage considerations

It can be taken with or without food.

Active ingredient


Valaciclovir, an antiviral, is the L-valine ester of aciclovir. Valaciclovir is rapidly and almost completely converted in man to aciclovir and valine. Aciclovir is a specific inhibitor of the herpes viruses with in vitro activity against herpes simplex viruses (HSV) type 1 and type 2, varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr Virus (EBV), and human herpes virus 6 (HHV-6).

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