Blast crisis in chronic myeloid leukaemia

Active Ingredient: Mitoxantrone

Indication for Mitoxantrone

Population group: only adults (18 years old or older)

Mitoxantrone in combination regimens is indicated in the remission-induction treatment of blast crisis in chronic myeloid leukaemia.

For this indication, competent medicine agencies globally authorize below treatments:

10-12 mg/m² once a day for 5 days

Route of admnistration


Defined daily dose

12 - 12 mg per m² of body surface area (BSA)

Dosage regimen

From 12 To 12 mg per m² of body surface area (BSA) once every day for 5 day(s)

Detailed description

Single dose therapy in relapse: The recommended dosage in relapse is 10 to 12 mg/m² body surface area given as a single intravenous dose daily over 5 consecutive days (total of 50 to 60 mg/m²).

Dosage considerations

Mitoxantrone concentrate should be slowly injected into a free flow lowing intravenous infusion of isotonic saline or 5% glucose solution over a period of not less than 3 to 5 minutes. The tubing should be inserted preferably into a large vein. If possible, avoid veins over joints or in extremities with compromised venous or lymphatic drainage.

Active ingredient


Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA.

Read more about Mitoxantrone

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