Mitoxantrone

Active ingredient description

Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
Classification
L01DB07
Mitoxantrone
L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01D Cytotoxic antibiotics and related substances → L01DB Anthracyclines and related substances
Discover more medicines within L01DB07

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title
Type
Country
MITOXANTRONE Concentrate for solution for infusion
Summary of Product Characteristics (SPC)
UK

Medicines

Mitoxantrone is the active ingredient of these drugs:

Drug
Countries
EBEXANTRON

Austria Tunisia

ELSEP

France

EVOMIXAN

Brazil

FORMYXAN

Ecuador

NOVANTRON

Japan

NOVANTRONE

France Spain

ONKOTRONE

Australia Estonia Lithuania New Zealand Romania

SANTRONE

Hong Kong

Structural formula

Graphic representation of the active ingredient's molecular structure

Chemical formula: C₂₂H₂₈N₄O₆
Molecular mass: 444.481 g/mol

External identifiers

CAS Substance: 65271-80-9
CAS Substance: 70476-82-3
DrugBank Drug: DB01204
KEGG Drug: D08224
PubChem Compound: 4212
RxNorm Ingredient: 7005
SNOMED-CT Concept: 386913001
Mitoxantrone (substance)
UNII Identifier: BZ114NVM5P
MITOXANTRONE
 
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