Renal disease in hypertensive patients with type 2 diabetes mellitus

Active Ingredient: Lisinopril

Indication for Lisinopril

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Treatment of renal disease in hypertensive patients with type 2 diabetes mellitus and incipient nephropathy.

For this indication, competent medicine agencies globally authorize below treatments:

10 mg once daily and thereafter 10-20 mg once daily

For:

Dosage regimens

Oral, 10 milligrams lisinopril, once daily. Afterwards, oral, between 10 milligrams lisinopril and 20 milligrams lisinopril, once daily.

Detailed description

In hypertensive patients with type 2 diabetes mellitus and incipient nephropathy, the dose is 10 mg lisinopril once daily which can be increased to 20 mg once daily, if necessary, to achieve a sitting diastolic blood pressure below 90 mmHg.

In cases of renal impairment (creatinine clearance <80 ml/min), the initial lisinopril dosage should be adjusted according to the patient’s creatinine clearance.

Dosage considerations

Lisinopril should be taken at approximately the same time each day. The absorption of lisinopril is not affected by food.

Active ingredient

Lisinopril

Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin-converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of angiotensin II which results in decreased vasopressor activity and reduced aldosterone secretion.

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