Active Ingredient: Orphenadrine

Indication for Orphenadrine

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Orphenadrine hydrochloride is an anticholinergic, for the treatment of all forms of Parkinsonism, including drug induced (neuroleptic syndrome).

For this indication, competent medicine agencies globally authorize below treatments:

150-400 mg in divided doses daily


Dosage regimens

Oral, between 150 milligrams orphenadrine and 400 milligrams orphenadrine, divided daily, 3 to 8 doses in total.

Detailed description

Initially, 150mg daily in divided doses, increasing by 50mg every two or three days until maximum benefit is obtained. Optimal dosage is usually 250mg to 300mg daily in divided doses in idiopathic and post-encephalitic Parkinsonism; 100mg to 150mg daily in divided doses in arteriosclerotic parkinsonism; and 150mg to 300mg daily in divided doses in the neuroleptic syndrome.

Maximal dosage is 400mg daily in divided doses. The elderly may be more susceptible to side effects at doses which are clinically optimal.

Active ingredient


Orphenadrine, which is a congener of diphenhydramine without sharing its soporific effect, is an anti-muscarinic agent. Orphenadrine is used as the hydrochloride in the symptomatic treatment of Parkinsonism.

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