Nausea and vomiting associated with chemotherapy and radiotherapy

Active Ingredient: Granisetron

Indication for Granisetron

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Granisetron is indicated in children aged 2 years and above for the treatment of acute nausea and vomiting associated with chemotherapy and radiotherapy.

For this indication, competent medicine agencies globally authorize below treatments:

10-40 ยตg/kg

Route of admnistration


Defined daily dose

10 - 40 ug per kg of body weight

Dosage regimen

From 10 To 40 ug per kg of body weight once every day

Detailed description

The safety and efficacy of granisetron in children aged 2 years and above has been well established for the prevention and treatment (control) of acute nausea and vomiting associated with chemotherapy. A dose of 10–40 ยตg/kg body weight (up to 3 mg) should be administered as an IV infusion, diluted in 10-30 ml infusion fluid and administered over 5 minutes prior to the start of chemotherapy. One additional dose may be administered within a 24 hour-period if required. This additional dose should not be administered until at least 10 minutes after the initial infusion.

Dosage considerations

It should be administered either as a slow intravenous injection or as a diluted intravenous infusion 5 minutes prior to the start of chemotherapy or radiotherapy.

Active ingredient


Granisetron is a potent anti-emetic and highly selective antagonist of 5-hydroxytryptamine (5HT3 receptors). Pharmacological studies have demonstrated that granisetron is effective against nausea and vomiting as a result of cytostatic therapy.

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