Granisetron

Chemical formula: C₁₈H₂₄N₄O  Molecular mass: 312.417 g/mol  PubChem compound: 5284566

Active ingredient description

Granisetron is a potent anti-emetic and highly selective antagonist of 5-hydroxytryptamine (5HT3 receptors). Pharmacological studies have demonstrated that granisetron is effective against nausea and vomiting as a result of cytostatic therapy.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A04AA02 Granisetron A Alimentary tract and metabolism → A04 Antiemetics and antinauseants → A04A Antiemetics and antinauseants → A04AA Serotonin (5HT3) antagonists
Discover more medicines within A04AA02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
GRANISETRON Film-coated tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
SANCUSO Transdermal patch European Medicines Agency (EU) MPI, EU: SmPC
GRANISETRON Concentrate for solution for injection or infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 109889-09-0
DrugBank Drug: DB00889
KEGG Drug: D04370
PubChem Compound: 5284566
RxNorm Ingredient: 26237
SNOMED-CT Concept: 372489005
Granisetron (substance)
UNII Identifier: WZG3J2MCOL
GRANISETRON

Medicines

Granisetron is an active ingredient of these brands:

United States (US)

Australia (AU)

  • KYTRIL as GRANISETRON HYDROCHLORIDE

Austria (AT)

Brazil (BR)

  • GRANDAX as GRANISETRON HYDROCHLORIDE
  • KYTRIL as GRANISETRON HYDROCHLORIDE

Croatia (HR)

Ecuador (EC)

  • KYTRIL as GRANISETRON HYDROCHLORIDE

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

  • AXIGRAN as GRANISETRON HYDROCHLORIDE
  • KEVATRIL as GRANISETRON HYDROCHLORIDE

Hong Kong (HK)

Ireland (IE)

Italy (IT)

Japan (JP)

  • KYTRIL as GRANISETRON HYDROCHLORIDE

Lithuania (LT)

Mexico (MX)

  • KYTRIL as GRANISETRON HYDROCHLORIDE

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

  • KYTRIL as GRANISETRON HYDROCHLORIDE

Tunisia (TN)

Turkey (TR)

  • EMETRIL as GRANISETRON HYDROCHLORIDE
  • FASTIDEND as GRANISETRON HYDROCHLORIDE
  • GRANEXA as GRANISETRON HYDROCHLORIDE
  • GRANIDUR as GRANISETRON HYDROCHLORIDE
  • GRANITON as GRANISETRON HYDROCHLORIDE
  • GRANITRON as GRANISETRON HYDROCHLORIDE
  • GRANSET as GRANISETRON HYDROCHLORIDE
  • GRATRYL as GRANISETRON HYDROCHLORIDE
  • GRONSIT as GRANISETRON HYDROCHLORIDE
  • KYTRIL as GRANISETRON HYDROCHLORIDE
  • NEOSET as GRANISETRON HYDROCHLORIDE
  • RASETRON as GRANISETRON HYDROCHLORIDE
  • SETREX as GRANISETRON HYDROCHLORIDE
  • SINAREX as GRANISETRON HYDROCHLORIDE
  • TIGRON as GRANISETRON HYDROCHLORIDE
  • VITASETRON as GRANISETRON HYDROCHLORIDE

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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