Active Ingredient: Rifampicin
For this indication, competent medicine agencies globally authorize below treatments:
Oral
10 - 10 mg per kg of body weight
From 10 To 10 mg per kg of body weight once every day
600 mg doses of rifampicin should be given once per month. Alternatively, a daily regimen may be used. The recommended single daily dose is 10 mg/kg.
Usual daily dose:
Patients weighing less than 50 kg – 450 mg.
Patients weighing 50 kg or more – 600 mg.
In the treatment of leprosy, rifampicin should always be used in conjunction with at least one other antileprosy drug.
In elderly patients, the renal excretion of rifampicin is decreased proportionally with physiological decrease of renal function; due to compensatory increase of liver excretion, the terminal half-life in serum is similar to that of younger patients. However, as increased blood levels have been noted in one study of rifampicin in elderly patients, caution should be exercised in using rifampicin in such patients, especially if there is evidence of impaired liver function.
The daily dose of rifampicin, calculated from the patient’s body weight, should preferably be taken at least 30 minutes before a meal or 2 hours after a meal to ensure rapid and complete absorption.
Intravenous
10 - 10 mg per kg of body weight
From 10 To 10 mg per kg of body weight once every day
The recommended daily dose is 10 mg/kg.
Usual daily dose:
Patients weighing less than 50 kg – 450 mg
Patients weighing 50 kg or more – 600 mg.
Alternatively, 600 mg doses of rifampicin may be given once per month.
In the treatment of leprosy, rifampicin should always be used in conjunction with at least one other antileprosy drug.
In elderly patients, the renal excretion of rifampicin is decreased proportionally with physiological decrease of renal function; due to compensatory increase of liver excretion, the terminal half-life in serum is similar to that of younger patients. However, as increased blood levels have been noted in one study of rifampicin in elderly patients, caution should be exercised in using rifampicin in such patients, especially if there is evidence of impaired liver function.
Intravenous infusion over 2 to 3 hours.
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