Active Ingredient: Vortioxetine
Vortioxetine is indicated for the treatment of major depressive episodes in adults.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 10 milligrams vortioxetine, once daily. Afterwards, oral, between 5 milligrams vortioxetine and 20 milligrams vortioxetine, once daily.
The starting and recommended dose is 10 mg vortioxetine once daily in adults less than 65 years of age.
Depending on individual patient response, the dose may be increased to a maximum of 20 mg vortioxetine once daily or decreased to a minimum of 5 mg vortioxetine once daily.
After the depressive symptoms resolve, treatment for at least 6 months is recommended for consolidation of the antidepressive response.
A gradual reduction in dosage may be considered to avoid the occurrence of discontinuation symptoms. However, there is insufficient data to provide specific recommendations for a tapering schedule for patients treated with vortioxetine.
For:
Oral, 5 milligrams vortioxetine, once daily. Afterwards, oral, between 5 milligrams vortioxetine and 10 milligrams vortioxetine, once daily.
The lowest effective dose of 5 mg vortioxetine once daily should always be used as the starting dose in patients ≥65 years of age. Caution is advised when treating patients ≥65 years of age with doses higher than 10 mg vortioxetine once daily for which data are limited.
A gradual reduction in dosage may be considered to avoid the occurrence of discontinuation symptoms. However, there is insufficient data to provide specific recommendations for a tapering schedule for patients treated with vortioxetine.
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