Major depressive episodes

Active Ingredient: Vortioxetine

Indication for Vortioxetine

Population group: only adults (18 - 65 years old)

Vortioxetine is indicated for the treatment of major depressive episodes in adults.

For this indication, competent medicine agencies globally authorize below treatments:

5-20 mg once daily

Route of admnistration

Oral

Defined daily dose

5 - 20 mg

Dosage regimen

From 5 To 20 mg once every day

Loading dose

10 mg

Detailed description

The starting and recommended dose of vortioxetine is 10 mg once daily in adults less than 65 years of age.

Depending on individual patient response, the dose may be increased to a maximum of 20 mg vortioxetine once daily or decreased to a minimum of 5 mg vortioxetine once daily.

After the depressive symptoms resolve, treatment for at least 6 months is recommended for consolidation of the antidepressive response.

Treatment discontinuation: Patients treated with vortioxetine can abruptly stop taking the medicinal product without the need for a gradual reduction in dose.

Active ingredient

Vortioxetine

Vortioxetine is a 5-HT3, 5-HT7, and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the 5-HT transporter, leading to modulation of neurotransmission in several systems, including predominantly the serotonin but probably also the norepinephrine, dopamine, histamine, acetylcholine, GABA and glutamate systems. This multimodal activity is considered responsible for the antidepressant and anxiolytic-like effects and the improvement of cognitive function, learning and memory observed with vortioxetine in animal studies.

Read more about Vortioxetine

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