Vortioxetine

Chemical formula: C₁₈H₂₂N₂S  Molecular mass: 298.45 g/mol  PubChem compound: 71768094

Active ingredient description

Vortioxetine is a 5-HT3, 5-HT7, and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the 5-HT transporter, leading to modulation of neurotransmission in several systems, including predominantly the serotonin but probably also the norepinephrine, dopamine, histamine, acetylcholine, GABA and glutamate systems. This multimodal activity is considered responsible for the antidepressant and anxiolytic-like effects and the improvement of cognitive function, learning and memory observed with vortioxetine in animal studies.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N06AX26 N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AX Other antidepressants
Discover more medicines within N06AX26

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
BRINTELLIX Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 508233-74-7
DrugBank Drug: DB09068
KEGG Drug: D10184
PubChem Compound: 71768094
RxNorm Ingredient: 1455099
SNOMED-CT Concept: 708717008
Vortioxetine (substance)
UNII Identifier: 3O2K1S3WQV
VORTIOXETINE

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