Fibrinolytic response testing

Active Ingredient: Desmopressin

Indication for Desmopressin

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)
Therapeutic intent: Diagnostic

For this indication, competent medicine agencies globally authorize below treatments:

0.4 ug/kg body weight once

For:

Dosage regimens

Intravenous, 0.4 micrograms desmopressin per kilogram of body weight, one dose.

Detailed description

The dose for adults and children is 0.4 micrograms per kilogram body weight administered by intravenous infusion. The dose should be diluted in 50ml of 0.9% sodium chloride for injection and given over 20 minutes.

A sample of venous blood should be taken 20 minutes after the infusion. In patients with a normal response the sample should show fibrinolytic activity of euglobulin clot precipitate on fibrin plates of at least 240mm².

Active ingredient

Desmopressin

Desmopressin is a structural analogue of vasopressin in which the antidiuretic activity has been enhanced by the order of 10, while the vasopressor effect has been reduced by the order of 1500. The clinical advantage of this highly changed ratio of antidiuretic to vasopressor effect is that clinically active antidiuretic doses are far below the threshold for a vasopressor effect.

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