Desmopressin

Chemical formula: C₄₆H₆₄N₁₄O₁₂S₂  Molecular mass: 1,069.22 g/mol 

Active ingredient description

Desmopressin is a structural analogue of vasopressin in which the antidiuretic activity has been enhanced by the order of 10, while the vasopressor effect has been reduced by the order of 1500. The clinical advantage of this highly changed ratio of antidiuretic to vasopressor effect is that clinically active antidiuretic doses are far below the threshold for a vasopressor effect.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
H01BA02 Desmopressin H Systemic hormonal preparations, excl. Sex hormones and insulins → H01 Pituitary and hypothalamic hormones and analogues → H01B Posterior pituitary lobe hormones → H01BA Vasopressin and analogues
Discover more medicines within H01BA02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
DDAVP MELT Oral lyophilisate Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
OCTOSTIM Solution for injection Health Products and Food Branch (CA) MPI, CA: SPM
DESMOTABS Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
DESMOPRESSIN Nasal spray, solution Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
DDAVP DESMOPRESSIN Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 16679-58-6
CAS Substance: 62357-86-2
DrugBank Drug: DB00035
KEGG Drug: D00291
RxNorm Ingredient: 3251
SNOMED-CT Concept: 126189002
Desmopressin (substance)
UNII Identifier: ENR1LLB0FP
DESMOPRESSIN

Medicines

Desmopressin is an active ingredient of these brands:

United States (US)

  • DDAVP as DESMOPRESSIN ACETATE
  • STIMATE as DESMOPRESSIN ACETATE

Australia (AU)

Austria (AT)

Brazil (BR)

  • DDAVP as DESMOPRESSIN ACETATE

Canada (CA)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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