Active Ingredient: Diazoxide
Diazoxide is used particularly for the emergency treatment of acute hypertensive crises, especially those occurring in association with acute hypertensive encephalopathy, congestive heart failure, acute glomerular nephitis, eclampsia or pre-eclampsia.
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
150 - 600 mg
From 150 To 600 mg once every day
A full dose of 300 mg in 20 ml will be required by most patients. However, an adequate fall in blood pressure in some patients may be obtained with as little as 150 mg. Patients must be recumbent during the injection which must be rapid and not exceed 30 seconds. Diazoxide injection should not be administered in a bolus dose of 300 mg since single intravenous doses of 300 mg have been associated with myocardial and cerebral infarction.
A response occurs within five minutes and usually persists for a least four hours. One injection is usually effective, but further injections may be required, particularly in hypertensive crises or in accelerating disease refractory to other hypotensive agents. Up to four ampoules may be given in 24 hours.
An initial dose of 600 mg is recommended only in life-threatening situations. Once the blood pressure is controlled by diazoxide injection, treatment with anti-hypertensive agents designed for maintenance can be initiated. It appears that if hypertensive patients treated with diazoxide injection are allowed an unrestricted sodium intake then the subsequent response to oral hypotensive agents will be improved.
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