Major depressive disorder

Active Ingredient: Amitriptyline

Indication for Amitriptyline

Population group: only elderly (65 years old or older)

Amitriptyline is indicated for the treatment of major depressive disorder.

For this indication, competent medicine agencies globally authorize below treatments:

10-150mg daily

Route of admnistration

Oral

Defined daily dose

25 - 150 mg

Dosage regimen

From 12.5 To 75 mg 2 time(s) per day every day for 180 day(s)

Detailed description

Initially 10 mg–25 mg daily. The daily dose may be increased up to 100 mg–150 mg divided into two doses, depending on individual patient response and tolerability. Doses above 100 mg should be used with caution.

The maintenance dose is the lowest effective dose.

Duration of treatment

The antidepressant effect usually sets in after 2-4 weeks. Treatment with antidepressants is symptomatic and must therefore be continued for an appropriate length of time usually up to 6 months after recovery in order to prevent relapse.

Active ingredient

Amitriptyline

Amitriptyline is a tricyclic antidepressant and an analgesic. It prevents the re-uptake, and hence the inactivation of noradrenaline and serotonin at nerve terminals. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity.

Read more about Amitriptyline

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