Paediatric plaque psoriasis

Active Ingredient: Adalimumab

Indication for Adalimumab

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Adalimumab is indicated for the treatment of severe chronic plaque psoriasis in children and adolescents from 4 years of age who have had an inadequate response to or are inappropriate candidates for topical therapy and phototherapies.

For this indication, competent medicine agencies globally authorize below treatments:

Initial dose of 20-40 mg, followed by 20-40 mg given every other week

Route of admnistration

Subcutaneous

Defined daily dose

20 - 40 mg

Dosage regimen

From 20 To 40 mg once every 14 day(s)

Detailed description

The recommended adalimumab dose for patients with plaque psoriasis from 4 to 17 years of age is based on body weight (Table). Adalimumab is administered via subcutaneous injection.

Adalimumab Dose for Paediatric Patients with Plaque Psoriasis:

Patient Weight Dosing Regimen
15 kg to <30 kg Initial dose of 20 mg, followed by 20 mg given every other week starting one week after the initial dose
≥30 kg Initial dose of 40 mg, followed by 40 mg given every other week starting one week after the initial dose

Continued therapy beyond 16 weeks should be carefully considered in a patient not responding within this time period.

If retreatment with adalimumab is indicated, the above guidance on dose and treatment duration should be followed.

The safety of adalimumab in paediatric patients with plaque psoriasis has been assessed for a mean of 13 months.

There is no relevant use of adalimumab in children aged less than 4 years for this indication.

Adalimumab may be available in other strengths and/or presentations depending on the individual treatment needs.

Active ingredient

Adalimumab

Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 0.1-0.2 nM).

Read more about Adalimumab

Related medicines

Develop a tailored medication plan for your case, considering factors such as age, gender, and health history

Ask the Reasoner

Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.