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Adalimumab

Description

Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 0.1-0.2 nM).

ATC Classification

Code
Title
Category
L04AB04
Adalimumab
L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AB Tumor necrosis factor alpha (TNF-α) inhibitors

Trade names

Trade name
Countries

Australia Austria Cyprus France Netherlands

Austria

Australia

Austria

Austria

Austria France Netherlands

Australia Austria Canada Cyprus France

Australia Austria Cyprus France Netherlands

Australia Austria Cyprus France Netherlands

Austria Cyprus France Netherlands

Product Monographs

Monograph
Type
Country
HUMIRA 40mg/0.4ml Solution for injection in pre-filled syringe / pen
MPI, EU: SmPC
HUMIRA 40mg/0.8ml Solution for injection
MPI, EU: SmPC
HUMIRA 40mg/0.8ml Solution for injection in pre-filled syringe / pen
MPI, EU: SmPC
HUMIRA 20mg Solution for injection in pre-filled syringe
MPI, EU: SmPC
HUMIRA 80mg Solution for injection in pre-filled syringe / pen
MPI, EU: SmPC