Adalimumab

Active ingredient description

Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 0.1-0.2 nM).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L04AB04 Adalimumab L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AB Tumor necrosis factor alpha (TNF-α) inhibitors
Discover more medicines within L04AB04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
HUMIRA 80mg Solution for injection in pre-filled syringe / pen European Medicines Agency (EU) MPI, EU: SmPC
HUMIRA 40mg/0.4ml Solution for injection in pre-filled syringe / pen European Medicines Agency (EU) MPI, EU: SmPC
HUMIRA 20mg Solution for injection in pre-filled syringe European Medicines Agency (EU) MPI, EU: SmPC
HUMIRA 40mg/0.8ml Solution for injection in pre-filled syringe / pen European Medicines Agency (EU) MPI, EU: SmPC
HUMIRA 40mg/0.8ml Solution for injection European Medicines Agency (EU) MPI, EU: SmPC

2D molecular structure

2D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 331731-18-1
DrugBank Drug: DB00051
KEGG Drug: D02597
RxNorm Ingredient: 327361
SNOMED-CT Concept: 407317001
Adalimumab (substance)
UNII Identifier: FYS6T7F842
ADALIMUMAB

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