Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 0.1-0.2 nM).
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L04AB04 | Adalimumab | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AB Tumor necrosis factor alpha (TNF-α) inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| HUMIRA 40mg/0.8ml Solution for injection in pre-filled syringe / pen | European Medicines Agency (EU) | MPI, EU: SmPC | |
| HUMIRA 80mg Solution for injection in pre-filled syringe / pen | European Medicines Agency (EU) | MPI, EU: SmPC | |
| HUMIRA 40mg/0.8ml Solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC | |
| HUMIRA 20mg Solution for injection in pre-filled syringe | European Medicines Agency (EU) | MPI, EU: SmPC | |
| HUMIRA 40mg/0.4ml Solution for injection in pre-filled syringe / pen | European Medicines Agency (EU) | MPI, EU: SmPC |
Adalimumab is an active ingredient of these brands:
United States (US)Austria (AT)Brazil (BR)Croatia (HR)Estonia (EE)Ireland (IE)Japan (JP)Lithuania (LT)Poland (PL)South Africa (ZA)Tunisia (TN)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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