Adalimumab
Active ingredient description
Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also modulates biological responses that are induced or regulated by TNF, including changes in the levels of adhesion molecules responsible for leukocyte migration (ELAM-1, VCAM-1, and ICAM-1 with an IC50 of 0.1-0.2 nM).
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| L04AB04 | Adalimumab | L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AB Tumor necrosis factor alpha (TNF-α) inhibitors |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| HUMIRA 80mg Solution for injection in pre-filled syringe / pen | MPI, EU: SmPC | European Medicines Agency (EU) | |
| HUMIRA 40mg/0.4ml Solution for injection in pre-filled syringe / pen | MPI, EU: SmPC | European Medicines Agency (EU) | |
| HUMIRA 40mg/0.8ml Solution for injection in pre-filled syringe / pen | MPI, EU: SmPC | European Medicines Agency (EU) | |
| HUMIRA 20mg Solution for injection in pre-filled syringe | MPI, EU: SmPC | European Medicines Agency (EU) | |
| HUMIRA 40mg/0.8ml Solution for injection | MPI, EU: SmPC | European Medicines Agency (EU) |
Medicines
Adalimumab is an active ingredient of these brands:
Albania (AL)Australia (AU)Austria (AT)Brazil (BR)Canada (CA)Croatia (HR)Cyprus (CY)Ecuador (EC)Estonia (EE)
Finland (FI)France (FR)Germany (DE)Hong Kong (HK)Ireland (IE)Israel (IL)Italy (IT)Japan (JP)Lithuania (LT)
Netherlands (NL)New Zealand (NZ)Poland (PL)
Romania (RO)Singapore (SG)South Africa (ZA)Spain (ES)Tunisia (TN)Turkey (TR)United Kingdom (UK)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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