Active Ingredient: Clonidine

Indication for Clonidine

Population group: only adults (18 - 65 years old)
Therapeutic intent: Curative procedure

Clonidine is indicated for the treatment of hypertension that has failed to respond adequately to other anti-hypertensives.

For this indication, competent medicine agencies globally authorize below treatments:

0.05-0.10 mg 3 times daily initial dosage and thereafter 0.3-1.2 mg in divided doses daily


Dosage regimens

Oral, between 0.15 milligrams clonidine and 0.3 milligrams clonidine, divided 2 to 3 times daily. Afterwards, oral, between 0.3 milligrams clonidine and 1.2 milligrams clonidine, divided 2 to 3 times daily.

Detailed description

The usual initial dosage is 0.05 to 0.10 mg three times daily with subsequent gradual increments to the level of optimal control generally in the daily dose range of 0.3 to 1.2 mg in divided doses although higher levels may be required.

Should clonidine be added to other anti-hypertensive therapy dosage of the latter should be gradually reduced as the clonidine is introduced.

Patients undergoing anaesthesia should continue their clonidine treatment before, during and after anaesthesia using oral or intravenous administration according to individual circumstances.

Active ingredient


Clonidine has been shown to have both central and peripheral sites of action. With long-term treatment clonidine reduces the responsiveness of peripheral vessels to vasoconstrictor and vasodilator substances and to sympathetic nerve stimulation. Early in treatment, however, blood pressure reduction is associated with a central reduction of sympathetic outflow and increased vagal tone.

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