Clonidine

Chemical formula: C₉H₉Cl₂N₃  Molecular mass: 230.094 g/mol  PubChem compound: 2803

Active ingredient description

Clonidine has been shown to have both central and peripheral sites of action. With long-term treatment clonidine reduces the responsiveness of peripheral vessels to vasoconstrictor and vasodilator substances and to sympathetic nerve stimulation. Early in treatment, however, blood pressure reduction is associated with a central reduction of sympathetic outflow and increased vagal tone.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C02AC01 Clonidine C Cardiovascular system → C02 Antihypertensives → C02A Antiadrenergic agents, centrally acting → C02AC Imidazoline receptor agonists
Discover more medicines within C02AC01
N02CX02 Clonidine N Nervous system → N02 Analgesics → N02C Antimigraine preparations → N02CX Other antimigraine preparations
Discover more medicines within N02CX02
S01EA04 Clonidine S Sensory organs → S01 Ophthalmologicals → S01E Antiglaucoma preparations and miotics → S01EA Sympathomimetics in glaucoma therapy
Discover more medicines within S01EA04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ONYDA Extended-release oral suspension FDA, National Drug Code (US) MPI, US: SPL/PLR
CATAPRES Tablet Health Products Regulatory Authority (IE) MPI, EU: SmPC
CATAPRES Solution for injection Health Products Regulatory Authority (IE) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 4205-90-7
CAS Substance: 4205-91-8
DrugBank Drug: DB00575
KEGG Drug: D00281
PubChem Compound: 2803
RxNorm Ingredient: 2599
SNOMED-CT Concept: 372805007
Clonidine (substance)
UNII Identifier: MN3L5RMN02
CLONIDINE

Medicines

Clonidine is an active ingredient of these brands:

United States (US)

  • CATAPRES as CLONIDINE HYDROCHLORIDE
  • DURACLON as CLONIDINE HYDROCHLORIDE
  • KAPVAY as CLONIDINE HYDROCHLORIDE
  • ONYDA as CLONIDINE HYDROCHLORIDE

Australia (AU)

Austria (AT)

Brazil (BR)

  • ATENSINA as CLONIDINE HYDROCHLORIDE
  • CLIZE as CLONIDINE HYDROCHLORIDE

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Ireland (IE)

Israel (IL)

Japan (JP)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

  • IPOREL as CLONIDINE HYDROCHLORIDE

South Africa (ZA)

Spain (ES)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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