ST segment elevation acute myocardial infarction in medically treated patients

Active Ingredient: Clopidogrel

Indication for Clopidogrel

Population group: only adults (18 years old or older)

Therapeutic intent: Preventive action

ST segment elevation acute myocardial infarction, in combination with ASA in medically treated patients eligible for thrombolytic/fibrinolytic therapy.

For this indication, competent medicine agencies globally authorize below treatments:

For patients <75 yearls old 300 mg loading dose and thereafter 75 mg once daily, and for patients ≥75 years old 75 mg once daily

For:

Dosage regimens

Regimen A: In case that patient age in years is < 75, oral, 300 milligrams clopidogrel, 1 one dose, over the duration of 1 day. Afterwards, in case that patient age in years is < 75, oral, 75 milligrams clopidogrel, once daily.

Regimen B: In case that patient age in years is ≥ 75, oral, 75 milligrams clopidogrel, once daily.

Detailed description

For medically treated patients eligible for thrombolytic/fibrinolytic therapy, clopidogrel should be given as a single daily dose of 75 mg initiated with a 300 mg loading dose in combination with ASA and with or without thrombolytics. For medically treated patients over 75 years of age clopidogrel should be initiated without a loading dose. Combined therapy should be started as early as possible after symptoms start and continued for at least four weeks. The benefit of the combination of clopidogrel with ASA beyond four weeks has not been studied in this setting.

If a dose is missed:

Within less than 12 hours after regular scheduled time: patients should take the dose immediately and then take the next dose at the regular scheduled time.
For more than 12 hours: patients should take the next dose at the regular scheduled time and should not double the dose.

Active ingredient

Clopidogrel
Clopidogrel is a prodrug, one of whose metabolites is an inhibitor of platelet aggregation. Clopidogrel must be metabolised by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation. Read more about Clopidogrel

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