Myocardial infarction

Active Ingredient: Clopidogrel

Indication for Clopidogrel

Population group: only adults (18 years old or older)

Clopidogrel is indicated in adult patients suffering from myocardial infarction (from a few days until less than 35 days).

For this indication, competent medicine agencies globally authorize below treatments:

75-300 mg once a day

Route of admnistration

Oral

Defined daily dose

75 - 300 mg

Dosage regimen

From 75 To 300 mg once every day

Loading dose

300 mg

Maintenance dose

75 mg

Detailed description

In patients suffering from acute coronary syndrome:

ST segment elevation acute myocardial infarction: clopidogrel should be given as a single daily dose of 75 mg initiated with a 300 mg loading dose in combination with ASA and with or without thrombolytics. For patients over 75 years of age clopidogrel should be initiated without a loading dose. Combined therapy should be started as early as possible after symptoms start and continued for at least four weeks. The benefit of the combination of clopidogrel with ASA beyond four weeks has not been studied in this setting.

If a dose is missed:

  • Within less than 12 hours after regular scheduled time: patients should take the dose immediately and then take the next dose at the regular scheduled time.
  • For more than 12 hours: patients should take the next dose at the regular scheduled time and should not double the dose.

Active ingredient

Clopidogrel

Clopidogrel is a prodrug, one of whose metabolites is an inhibitor of platelet aggregation. Clopidogrel must be metabolised by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation.

Read more about Clopidogrel

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