Lyme borreliosis

Indication for Cefotaxime

Population group: Suitable for both men and women, only adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

6 g in 3 divided doses daily

Route of admnistration


Defined daily dose

6 - 6 g

Dosage regimen

From 2 To 2 g 3 time(s) per day every day for 14 day(s)

Detailed description

A daily dose of 6 g cefotaxime (14 to 21 days duration). The daily dose was generally administered divided into 3 parts (2 g cefotaxime 3 times daily).

Dosage considerations

For IV, cefotaxime for injection 500mg is dissolved in at least 2 ml water for injections, Cefotaxime for injection 1 g in at least 4 ml and subsequently injected directly into the vein over 3 to 5 minutes or after clamping of the infusion tube into the distal end of the tube. During post-marketing surveillance, potentially life-threatening arrhythmia has been reported in a very few patients who received rapid intravenous administration of cefotaxime through a central venous catheter.


For brief infusion 2g of cefotaxime for injection is dissolved in 100 ml of isotonic sodium chloride or glucose solution and subsequently IV infused over 50 to 60 minutes. Another compatible infusion solution can also be used for the solution.

Active ingredient

Cefotaxime exerts its action by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thereby inhibiting cell wall synthesis.

Read more about Cefotaxime

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