Progesterone is indicated for adjunctive use with estrogen in post-menopausal women with an intact uterus, as hormone replacement therapy (HRT).
For this indication, competent medicine agencies globally authorize below treatments:
Oral
100 - 200 mg
From 100 To 200 mg once every day
In women receiving estrogen replacement therapy there is an increased risk of endometrial cancer which can be countered by progesterone administration.
The recommended dose is 200 mg daily at bedtime, for twelve days in the last half of each therapeutic cycle (beginning on Day 15 of the cycle and ending on Day 26). Withdrawal bleeding may occur in the following week.
Alternatively 100 mg can be given at bedtime from Day 1 to Day 25 of each therapeutic cycle, withdrawal bleeding being less with this treatment schedule.
Progesterone should not be taken with food and should be taken at bedtime.
Concomitant food ingestion increases the bioavailability of micronized progesterone.
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