Hormone replacement therapy (HRT)

Indication for Progesterone

Population group: Suitable for women, only adults (18 - 65 years old)

Progesterone is indicated for adjunctive use with estrogen in post-menopausal women with an intact uterus, as hormone replacement therapy (HRT).

For this indication, competent medicine agencies globally authorize below treatments:

100-200 mg once a day

Route of admnistration


Defined daily dose

100 - 200 mg

Dosage regimen

From 100 To 200 mg once every day

Detailed description

In women receiving estrogen replacement therapy there is an increased risk of endometrial cancer which can be countered by progesterone administration.

The recommended dose is 200 mg daily at bedtime, for twelve days in the last half of each therapeutic cycle (beginning on Day 15 of the cycle and ending on Day 26). Withdrawal bleeding may occur in the following week.

Alternatively 100 mg can be given at bedtime from Day 1 to Day 25 of each therapeutic cycle, withdrawal bleeding being less with this treatment schedule.

Dosage considerations

Progesterone should not be taken with food and should be taken at bedtime.

Concomitant food ingestion increases the bioavailability of micronized progesterone.

Active ingredient

Progesterone is a natural progestogen, the main hormone of the corpus luteum and the placenta. It acts on the endometrium by converting the proliferating phase to the secretory phase.

Read more about Progesterone

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