Testicular carcinoma

Active Ingredient: Cis-Diaminedichloroplatinum

Indication for Cis-Diaminedichloroplatinum

Population group: men, only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

To be used as mono-therapy, or as part of an existing chemotherapy for advanced or metastatic tumours of testicular carcinoma (palliative and curative poly-chemotherapy).

For this indication, competent medicine agencies globally authorize below treatments:

50-120 mg/m² once every 3-4 weeks

Route of admnistration

Intravenous

Defined daily dose

50 - 120 mg per m² of body surface area (BSA)

Dosage regimen

From 50 To 120 mg per m² of body surface area (BSA) once every 21 day(s)

Detailed description

The cisplatin dosage depends on the primary disease, the expected reaction, and on whether cisplatin is used for monotherapy or as a component of a combination chemotherapy. The dosage directions are applicable for both adults and children. For recommendations on the dosage applicable, based on the diagnosis and the clinical condition, the current medical literature should be consulted.

For monotherapy, the following two dosage regimens are recommended:

Single dose of 50 to 120 mg/m² body surface every 3 to 4 weeks; 15 to 20 mg/m²/day for five days, every 3 to 4 weeks.

If cisplatin is used in combination chemotherapy, the dose of cisplatin must be reduced. A typical dose is 20 mg/m² or more once every 3 to 4 weeks unless in the combination therapy of small-cell and non-small-cell lung carcinoma, in which a typical dose of 80 mg/m² is administered.

Further dosage recommendations are to be based upon current medical insights, to be obtained from the literature or/and the appropriate working parties.

In patients with renal dysfunction or bone marrow depression, the dose should be reduced adequately.

Dosage considerations

The cisplatin solution for infusion prepared according to instructions should be administered by intravenous infusion over a period of 6 to 8 hours.

15-20 mg/m² once for 5 days every 3-4 weeks

Route of admnistration

Intravenous

Defined daily dose

15 - 20 mg per m² of body surface area (BSA)

Dosage regimen

From 15 To 20 mg per m² of body surface area (BSA) once every day for 5 day(s)

Detailed description

The cisplatin dosage depends on the primary disease, the expected reaction, and on whether cisplatin is used for monotherapy or as a component of a combination chemotherapy. The dosage directions are applicable for both adults and children. For recommendations on the dosage applicable, based on the diagnosis and the clinical condition, the current medical literature should be consulted.

For monotherapy, the following two dosage regimens are recommended:

Single dose of 50 to 120 mg/m² body surface every 3 to 4 weeks; 15 to 20 mg/m²/day for five days, every 3 to 4 weeks.

If cisplatin is used in combination chemotherapy, the dose of cisplatin must be reduced. A typical dose is 20 mg/m² or more once every 3 to 4 weeks unless in the combination therapy of small-cell and non-small-cell lung carcinoma, in which a typical dose of 80 mg/m² is administered.

Further dosage recommendations are to be based upon current medical insights, to be obtained from the literature or/and the appropriate working parties.

In patients with renal dysfunction or bone marrow depression, the dose should be reduced adequately.

Dosage considerations

The cisplatin solution for infusion prepared according to instructions should be administered by intravenous infusion over a period of 6 to 8 hours.

Active ingredient

Cis-Diaminedichloroplatinum

Cisplatin is an anorganic substance containing a heavy metal [cis-diamminedichloroplatinum(II)]. This substance inhibits the DNA synthesis by realising transverse connections within and between the DNA strings. The protein and RNA synthesis is inhibited to a lesser extent.

Read more about Cis-Diaminedichloroplatinum

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