Chronic heart failure

Indication for Cilazapril

Population group: Suitable for both men and women, only adults (18 - 65 years old)

Cilazapril is indicated for the treatment of chronic heart failure.

For this indication, competent medicine agencies globally authorize below treatments:

0.5-5.0 mg once daily

Route of admnistration


Defined daily dose

0.5 - 5 mg

Dosage regimen

From 0.5 To 5 mg once every day

Loading dose

0.5 mg

Detailed description

Therapy with cilazapril should be initiated at a recommended starting dose of 0.5 mg once daily under close medical supervision. This dose should be maintained for about 1 week. If this dose has been well tolerated it may be increased in weekly intervals and according to the clinical status of the patient to 1.0 mg or 2.5 mg. The maximum daily dose for these patients is 5.0 mg. The posology recommendation for cilazapril in chronic heart failure is based on effects on symptomatic improvement, rather than on data showing that cilazapril reduces morbidity and mortality in this patient group.

Dosage considerations

As food intake has no clinically significant influence on absorption, cilazapril can be administered before or after a meal. The dose should always be taken at about the same time of day.

Active ingredient

Cilazapril is a specific, long-acting angiotensin-converting enzyme (ACE) inhibitor which suppresses the renin-angiotensin-aldosterone system and thereby the conversion of the inactive angiotensin I to angiotensin II, which is a potent vasoconstrictor.

Read more about Cilazapril

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