Granisetron is indicated in adults for the treatment of acute nausea and vomiting associated with chemotherapy and radiotherapy.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
2 - 2 mg
From 1 To 1 mg 2 time(s) per day every day
1 mg twice a day or 2 mg once a day for up to one week following radiotherapy or chemotherapy. The first dose of granisetron should be administered within one hour before the start of therapy.
Dexamethasone has been used concomitantly at doses up to 20 mg once a day orally.
The first dose of granisetron should be administered within one hour before the start of therapy.
Intravenous
1 - 9 mg
From 0.333 To 3 mg 3 time(s) per day every day
A dose of 1–3 mg (10–40 µg/kg) of granisetron should be administered either as a slow intravenous injection or as a diluted intravenous infusion and administered over 5 minutes. The solution should be diluted to 5 ml per mg. Further maintenance doses of Granisetron may be administered at least 10 minutes apart. The maximum dose to be administered over 24 hours should not exceed 9 mg.
The efficacy of parenteral granisetron may be enhanced by an additional intravenous dose of an adrenocortical steroid e.g. by 8-20 mg dexamethasone administered before the start of the cytostatic therapy or by 250 mg methyl-prednisolone administered prior to the start and shortly after the end of the chemotherapy.
It should be administered either as a slow intravenous injection or as a diluted intravenous infusion 5 minutes prior to the start of chemotherapy or radiotherapy.
Intravenous
10 - 120 ug per kg of body weight
From 3.333 To 40 ug per kg of body weight 3 time(s) per day every day
A dose of 1–3 mg 10–40 µg/kg of granisetron should be administered either as a slow intravenous injection or as a diluted intravenous infusion and administered over 5 minutes. The solution should be diluted to 5 ml per mg. Further maintenance doses of Granisetron may be administered at least 10 minutes apart. The maximum dose to be administered over 24 hours should not exceed 9 mg.
The efficacy of parenteral granisetron may be enhanced by an additional intravenous dose of an adrenocortical steroid e.g. by 8-20 mg dexamethasone administered before the start of the cytostatic therapy or by 250 mg methyl-prednisolone administered prior to the start and shortly after the end of the chemotherapy.
It should be administered either as a slow intravenous injection or as a diluted intravenous infusion 5 minutes prior to the start of chemotherapy or radiotherapy.
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