Active Ingredient: Melphalan
Melphalan is effective in the treatment of a proportion of patients suffering from polycythaemia vera.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, between 6 milligrams melphalan and 10 milligrams melphalan, once daily, over the duration of 5 to 7 days. Afterwards, oral, between 2 milligrams melphalan and 4 milligrams melphalan, once daily.
For remission induction the usual dose is 6-10 mg daily for 5-7 days, after which 2-4 mg daily is given until satisfactory disease control is achieved. Therapy is maintained with a dose of 2-6 mg per week. During maintenance therapy, careful haematological control is essential with dosage adjustment according to the results of frequent blood counts.
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