Chemical formula: C₁₃H₁₈Cl₂N₂O₂ Molecular mass: 305.2 g/mol PubChem compound: 460612
Melphalan is a bifunctional alkylating agent. Formation of carbonium intermediates from each of the two bis-2-chloroethyl groups enables alkylation through covalent binding with the 7-nitrogen of guanine on DNA, cross-linking the two DNA strands and thereby preventing cell replication.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01AA03 | Melphalan | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AA Nitrogen mustard analogues |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| MELPHALAN Film-coated tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| MELPHALAN Powder and solvent for solution for injection/infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Melphalan is an active ingredient of these brands:
Australia (AU)Brazil (BR)Canada (CA)Ecuador (EC)
Estonia (EE)
Finland (FI)Israel (IL)Japan (JP)Mexico (MX)Netherlands (NL)New Zealand (NZ)Singapore (SG)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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