Hypercholesterolaemia Fredrickson's Type II

Active Ingredient: Colestyramine

Indication for Colestyramine

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Reduction of plasma cholesterol in hypercholesterolaemia, particularly in those patients who have been diagnosed as Fredrickson’s Type II (high plasma cholesterol with normal or slightly elevated triglycerides).

For this indication, competent medicine agencies globally authorize below treatments:

0.05-0,05 g/kg in 1-2 divided doses daily

Route of admnistration


Defined daily dose

0.05 - 0.5 g per kg of body weight

Dosage regimen

From 0.025 To 0.25 g per kg of body weight 2 time(s) per day every day

Detailed description

The initial dose is determined by the following formula: Child’s Weight in Kg x Adult Dose / 70

Subsequent dosage adjustment may be necessary where clinically indicated.

To minimize potential gastrointestinal side effects, it is desirable to begin all therapy in children with one dose of Questran Light daily. The dosage is then increased gradually, every five to seven days to the desired level for effective control.

Dosage considerations

As a precautionary measure, where concurrent drug therapy exists then such drugs should be administered at least one hour before or 4-6 hours after colestyramine.

Colestyramine should not be taken in its dry form.

Colestyramine should be administered mixed with water or a suitable liquid, such as fruit juice, and stirred to a uniform consistency.

Colestyramine may also be mixed with skimmed milk, thin soups, pulpy fruits with high moisture content, e.g. apple sauce, etc.

Active ingredient


Colestyramine resin absorbs and combines with the bile acids in the intestine to form an insoluble complex which is excreted in the faeces. This results in an increased faecal loss of bile acids which leads to an increased oxidation of cholesterol to bile acids and a decrease in serum cholesterol levels and low density lipoprotein serum levels.

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