Active Ingredient: Anagrelide
Anagrelide is indicated for the reduction of elevated platelet counts in at risk essential thrombocythaemia (ET) patients who are intolerant to their current therapy or whose elevated platelet counts are not reduced to an acceptable level by their current therapy.
An at risk essential thrombocythaemia patient is defined by one or more of the following features:
For this indication, competent medicine agencies globally authorize below treatments:
Oral
1 - 10 mg
From 0.5 To 5 mg 2 time(s) per day every day
The recommended starting dose of anagrelide is 1 mg/day, which should be administered orally in two divided doses (0.5 mg/dose).
The starting dose should be maintained for at least one week. After one week the dose may be titrated, on an individual basis, to achieve the lowest effective dose required to reduce and/or maintain a platelet count below 600 × 109/l and ideally at levels between 150 × 109/l and 400 × 109/l. The dose increment must not exceed more than 0.5 mg/day in any one-week and the recommended maximum single dose should not exceed 2.5 mg. During clinical development doses of 10 mg/day have been used.
The effects of treatment with anagrelide must be monitored on a regular basis. If the starting dose is >1 mg/day platelet counts should be performed every two days during the first week of treatment and at least weekly thereafter until a stable maintenance dose is reached. Typically, a fall in the platelet count will be observed within 14 to 21 days of starting treatment and in most patients an adequate therapeutic response will be observed and maintained at a dose of 1 to 3 mg/day.
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