Anagrelide

Chemical formula: C₁₀H₇Cl₂N₃O  Molecular mass: 256.088 g/mol  PubChem compound: 135409400

Active ingredient description

Anagrelide is an inhibitor of cyclic AMP phosphodiesterase III and suppress expression of transcription factors including GATA-1 and FOG-1 required for megakaryocytopoiesis, ultimately leading to reduced platelet production.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
L01XX35 Anagrelide L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XX Other antineoplastic agents
Discover more medicines within L01XX35

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 XAGRID Capsule MPI, EU: SmPC European Medicines Agency (EU)
 AGRYLIN Capsule MPI, US: SPL/PLR FDA, National Drug Code (US)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 68475-42-3
DrugBank Drug: DB00261
KEGG Drug: D07455
PubChem Compound: 135409400
RxNorm Ingredient: 596724
SNOMED-CT Concept: 372561005
Anagrelide (substance)
UNII Identifier: K9X45X0051
ANAGRELIDE

Medicines

Anagrelide is an active ingredient of these brands:

Austria (AT)

Brazil (BR)

  • AGRYLIN as ANAGRELIDE HYDROCHLORIDE ANHYDROUS
  • MONBOC as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Canada (CA)

  • AGRYLIN as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Croatia (HR)

Cyprus (CY)

  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Estonia (EE)

  • GRALIDON as ANAGRELIDE HYDROCHLORIDE ANHYDROUS
  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Finland (FI)

  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

France (FR)

  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Germany (DE)

  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS
  • XERALID as ANAGRELIDE HYDROCHLORIDE

Hong Kong (HK)

  • AGRYLIN as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Ireland (IE)

  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Israel (IL)

  • ANAGRID as ANAGRELIDE HYDROCHLORIDE

Italy (IT)

  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Japan (JP)

  • AGRYLIN as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Lithuania (LT)

  • GRALIDON as ANAGRELIDE HYDROCHLORIDE ANHYDROUS
  • THROMBOREDUCTIN as ANAGRELIDE HYDROCHLORIDE ANHYDROUS
  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Netherlands (NL)

  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

New Zealand (NZ)

  • AGRYLIN as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Poland (PL)

Romania (RO)

Singapore (SG)

  • AGRYLIN as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

South Africa (ZA)

  • AGRYLIN as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Spain (ES)

  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Turkey (TR)

United Kingdom (UK)

  • XAGRID as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

United States (US)

  • AGRYLIN as ANAGRELIDE HYDROCHLORIDE ANHYDROUS

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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