Chemical formula: C₁₀H₇Cl₂N₃O  Molecular mass: 256.088 g/mol  PubChem compound: 135409400

Therapeutic indications

Anagrelide is indicated for:

Essential thrombocythemia

Population group: only adults (18 years old or older)

Anagrelide is indicated for the reduction of elevated platelet counts in at risk essential thrombocythaemia (ET) patients who are intolerant to their current therapy or whose elevated platelet counts are not reduced to an acceptable level by their current therapy.

An at risk patient

An at risk essential thrombocythaemia patient is defined by one or more of the following features:

  • >60 years of age or
  • a platelet count >1000 × 109/l or
  • a history of thrombo-haemorrhagic events.

For this indication, competent medicine agencies globally authorize below treatments (click for details):


Anagrelide is contraindicated in the following cases:

Moderate or severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Moderate or severe hepatic impairment

at least one of
Hepatic failure stage II
Hepatic failure stage III
Hepatic failure stage IV

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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