Post-operative nausea and vomiting

Active Ingredient: Tropisetron

Indication for Tropisetron

Population group: only adults (18 - 65 years old)

For this indication, competent medicine agencies globally authorize below treatments:

2 mg once

Route of admnistration

Intravenous

Defined daily dose

2 - 2 mg

Dosage regimen

From 2 To 2 mg once every day

Detailed description

Tropisetron is recommended as a 2 mg dose given intravenously either as an infusion or as a slow injection (not less than 30 seconds). In the case of prevention of post-operative nausea and vomiting, tropisetron should be administered shortly before the induction of anaesthesia.

Active ingredient

Tropisetron

Tropisetron is a highly potent and selective competitive antagonist of the 5-HT3 receptor. Tropisetron selectively blocks the excitation of the presynaptic 5-HT3 receptors of the peripheral neurons in this reflex, and may exert additional direct actions within the CNS on 5-HT3 receptors mediating the actions of vagal input to the area postrema.

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