Active Ingredient: Spironolactone
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, between 50 milligrams spironolactone and 100 milligrams spironolactone, once daily to meals.
Usual dose – 50 mg/day to 100 mg/day, which for difficult or severe cases may be gradually increased at 2 weekly intervals up to 200 mg/day. Treatment should be continued for 2 weeks or longer since an adequate response may not occur before this time. Dose should subsequently be adjusted according to the response of the patient.
It is recommended that treatment is started with the lowest dose and titrated upwards as required to achieve maximum benefit. Care should be taken in severe hepatic and renal impairment which may alter spironolactone metabolism and excretion.
Spironolactone should be taken together with a meal.
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