Chemical formula: C₂₄H₃₂O₄S Molecular mass: 416.573 g/mol PubChem compound: 5833
Spironolactone, as a competitive aldosterone antagonist, increases sodium excretion whilst reducing potassium loss at the distal renal tubule. It has a gradual and prolonged action.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C03DA01 | Spironolactone | C Cardiovascular system → C03 Diuretics → C03D Potassium-sparing agents → C03DA Aldosterone antagonists |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ALDACTONE Film-coated tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Spironolactone is an active ingredient of these brands:
United States (US)
Austria (AT)
Brazil (BR)
Canada (CA)Croatia (HR)Ecuador (EC)Estonia (EE)
Finland (FI)France (FR)
Germany (DE)
Israel (IL)Japan (JP)Lithuania (LT)Mexico (MX)
Nigeria (NG)Poland (PL)Romania (RO)
Spain (ES)
Tunisia (TN)
Turkey (TR)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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